TABLE 1.
Amino acid sequences of the V3, V4, and V5 populations detected in the HIV-1/JC499 inoculuma
| Population | Amino acid sequence |
|---|---|
| V3 (36 amino acids) | CTRPNYNETKRIRIHRGYGRSFVTVRKL?D?KQAHC |
| A | ............................G.R..... |
| B | ............................VNM.R... |
| V4 (27 to 34 amino acids) | CNSTKLFNSTWN--?T?ES---????E-N--ITLPC |
| 1 | .T..........--T.S..---D-TK.-.--..... |
| 2 | ............--D.T..---SGNG.-.--..... |
| 3 | .T..........--A.S..---DYPK.-.--..... |
| 5 | ............--G.V..---YNYG.-.--..... |
| 7 | ............VND.G.P----RYT.G.ST...Q. |
| 8 | ............VNS.WYATRESNYT.E.--..... |
| V5 (7 to 12 amino acids) | GP---????NET |
| a | -----DKTEH.. |
| b | .----HNTKK.. |
| c | ..---SGNK... |
| d | ..---DNNK... |
| f | .K---DNTN... |
| i | .K---ENTH... |
| j | .H---DKDK... |
| k | ..-SGNNIN... |
| l | ..-SGHNTN... |
| n | .H-DTSKNE... |
| p | ..SDKNNYH... |
a
Numbers and letters identifying specific V4 and V5 populations, respectively, are not sequential because clones found only in C-499’s PBMC, but not in cultured PBMC (P0) or HIV-1/JC499-P1, were omitted. Dots denote identity with the consensus sequences, dashes represent deletions or gaps to optimize alignments, and question marks are sites at which <50% of the sequences have the same amino acid.