TABLE 3.

Characteristics of and viral loads in HIV-1/JC499-infected chimpanzees

Chimpanzee	Inoculation route	No. of wks after inoculation	Antibody titera	Proviral copies per μg of DNA (SE)b	RNA copies per ml of plasmac
C-384	Intravenous	1	200	3.11 (1.78)	2.0 × 104
		2	1,600	1,534 (326)	2.1 × 107
		4	102,400		1.1 × 106
C-166	Cervical	1	800	Neg	Neg
		2	800	10.77 (3.62)	1.6 × 105
		4	204,800		4.9 × 106
		6	409,600	766 (466)	5.0 × 106
		12	204,800	818 (439)
				2,218 (1,634)
C-1323	Penile	4	100	0.61 (0.25)	5.0 × 102
		6	100	Neg	Neg
		8		1.52 (0.52)	Neg
				1.77 (0.66)
		12	100	Neg	Neg

^aAntibody titers in serum are the reciprocals of maximum serum dilutions that gave a positive optical density reading, as determined by enzyme immunoassay.

^bProviral copy numbers are those in PBMC except for the second values for C-166 at 12 weeks and C-1323 at 8 weeks, which represent proviral copy numbers in lymph nodes. Neg, multiple PCRs using up to 4 μg of DNA/reaction were negative.

^cNeg, no detectable virion RNA in 1 ml of plasma using the Roche Amplicor HIV-1 Monitor kit.