Table 2.
Relationship between eosinophils and MBE and functional outcome among patients with acute ischemic stroke in different models.
| Variable | Non-adjusted model | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| β/OR (95%CI) | P-value | β/OR (95%CI) | P-value | β/OR (95%CI) | P-value | |
| MBE | ||||||
| Eosinophils (standardized, per 1-SD increase)* | 0.152 (0.066, 0.351) | 0.00001 | 0.160 (0.069, 0.370) | 0.00002 | 0.165 (0.055, 0.498) | 0.00137 |
| Eosinophils (dichotomous)** | 0.222 (0.136, 0.360) | <0.00001 | 0.230 (0.141, 0.375) | <0.00001 | 0.168 (0.086, 0.328) | <0.00001 |
| Poor outcome (mRS score >2) | ||||||
| Eosinophils (standardized, per 1-SD increase)* | 0.574 (0.444, 0.742) | 0.00002 | 0.587 (0.456, 0.755) | 0.00003 | 0.620 (0.475, 0.810) | 0.00045 |
| Eosinophils (dichotomous)** | 0.215 (0.137, 0.337) | <0.00001 | 0.218 (0.136, 0.348) | <0.00001 | 0.179 (0.096, 0.333) | <0.00001 |
| mRS | ||||||
| Eosinophils (standardized, per 1-SD increase)* | −0.462 (−0.641, −0.283) | <0.00001 | −0.426 (−0.594, −0.258) | <0.00001 | −0.304 (−0.480, −0.128) | 0.00081 |
| Eosinophils (dichotomous)** | −1.437 (−1.783, −1.092) | <0.00001 | −1.270 (−1.597, −0.942) | <0.00001 | −1.073 (−1.421, −0.726) | <0.00001 |
Non-adjusted model: we did not adjust other covariates. Model 1: we adjusted age and sex. Model 2: we adjusted variables which were significantly associated with outcomes of interest (p < 0.10) or changed the estimates of eosinophils on outcomes of interest by more than 10%. CI, confidence interval; MBE, malignant brain edema; mRS, modified Rankin Scale. *Standardized eosinophils*: Z-score transformed using the formula Z = (X - 0.026) / 0.049, where X is the raw eosinophil count, 0.026 is the mean, and 0.049 is the standard deviation of the original distribution. OR indicates the risk change per 1 standard deviation increase in eosinophil count. **Dichotomous eosinophils: Categorized at the median value of 0.01* 10^9/L (low vs. high).