Skip to main content
. 2002 Jan;76(2):895–904. doi: 10.1128/JVI.76.2.895-904.2002

FIG. 2.

FIG. 2.

In vitro effects of wild-type (WT) VSV and rVSV on primary or transformed cells. (A to C) rVSVs efficiently kill transformed cells. HMVECs or B16(F10) or DA-3 cells were infected with wild-type VSV, VSV-TK, or VSV-IL-4 with (solid columns) or without (empty columns) prior treatment with IFN-α. Cell viability was assayed by trypan blue exclusion 18 h after infection. (D to F) Efficient replication of VSV-GFP in transformed cells. HMVECs or B16(F10) or DA-3 cells were infected with VSV-GFP with or without prior treatment of IFN-α (1,000 U/ml). Top panels show cells under bright field microscopy (magnification, ×20), and lower panels show the same field by immunofluorescence.