TABLE 2.
Antigenic analysis of H6 influenza viruses by HIa
| Virus | Titerb for:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Hyperimmune rabbit antisera against:
|
Postinfection chicken antisera against:
|
Postinfection ferret antiserum against Tl/HK/W312/97 | Monoclonal antibody against Tl/HK/W312/97 | |||||
| Tk/Mass/1/65 | Sh/Au/1/72 | WHO H6 reference | Ph/HK/SH39/99 | Gs/HK/W217/97 | Ck/HK/17/77 | |||
| Reference strains | ||||||||
| Tk/Mass/1/65 | 2,560 | 1,280 | 320 | 80 | 640 | 320 | < | < |
| Sh/Au/1/72 | 640 | 5,120 | 160 | 80 | 640 | 640 | < | < |
| WHO H6N1c | 1,280 | 1,280 | 320 | 320 | 80 | 320 | 160 | 5,120 |
| Contemporary terrestrial isolates | ||||||||
| Ph/HK/SH39/99 | 2,560 | 2,560 | 640 | 320 | 40 | 640 | 160 | 5,120 |
| Qa/HK/1721-20/99 | 1,280 | 2,560 | 320 | 320 | 40 | 320 | 160 | 5,120 |
| Qa/HK/1721-30/99 | 1,280 | 2,560 | 320 | 320 | 40 | 320 | 160 | 5,120 |
| Qa/HK/SF550/00 | 2,560 | 2,560 | 320 | 320 | 40 | 320 | 160 | 5,120 |
| Qa/HK/SF595/00 | 1,280 | 2,560 | 320 | 320 | 40 | 320 | 80 | 1,280 |
| Ph/HK/NT261/00 | 320 | 640 | 320 | 320 | 40 | 320 | 80 | 5,120 |
| Cu/HK/FY295/00 | 640 | 1,280 | 320 | 320 | 40 | 320 | 80 | 5,120 |
| Contemporary aquatic isolates | ||||||||
| Gs/HK/W217/97 | 640 | 640 | 80 | < | 640 | 640 | < | < |
| Gs/HK/W222/97 | 2,560 | 2,560 | 640 | < | 1,280 | 640 | < | < |
| Tl/HK/W312/97 | 1,280 | 2,560 | 320 | 320 | 80 | 320 | 160 | 5,120 |
| Gs/HK/W375/97 | 640 | 640 | < | < | 1,280 | < | < | < |
| Dk/HK/323/98 | 1,280 | 1,280 | < | < | 1,280 | 160 | < | < |
| Dk/HK/324/98 | 1,280 | 1,280 | < | < | 1,280 | 80 | < | < |
| Dk/HK/1037-1/98 | 160 | 160 | < | < | 640 | 40 | < | < |
| Dk/HK/1037-2/98 | 640 | 640 | < | < | 640 | 160 | < | < |
| Dk/HK/1037-3/98 | 640 | 640 | < | < | 640 | 160 | < | < |
| Dk/HK/1037-4/98 | 640 | 640 | < | < | 640 | 160 | < | < |
| Dk/HK/3096/99 | 320 | 640 | < | < | 320 | 160 | < | < |
| Dk/HK/3174/99 | 320 | 640 | 40 | < | 320 | 160 | < | < |
| Dk/HK/3461/99 | 640 | 2,560 | 80 | 80 | 160 | 1,280 | < | < |
| Dk/HK/3600/99 | 640 | 1,280 | 40 | < | 640 | 320 | < | < |
| 1970s isolates | ||||||||
| Dk/HK/73/76 | 1,280 | 5,120 | 80 | < | 320 | 640 | < | < |
| Dk/HK/108/76 | 640 | 2,560 | 40 | < | 160 | 320 | < | < |
| Dk/HK/134/77 | 2,560 | 5,120 | 80 | < | 160 | 2,560 | < | < |
| Dk/HK/175/77 | 320 | 2,560 | 40 | < | 160 | 320 | < | < |
| Dk/HK/182/77 | 640 | 2,560 | 160 | < | 640 | 1,280 | < | < |
| Dk/HK/202/77 | 640 | 2,560 | 80 | < | 320 | 640 | < | < |
| Dk/HK/221/77 | 640 | 2,560 | 160 | < | 320 | 1,280 | < | < |
| Gs/HK/17/77 | 1,280 | 5,120 | 160 | < | 320 | 1,280 | < | < |
| Ck/HK/17/77 | 1,280 | 5,120 | 160 | < | 320 | 640 | < | < |
a
Abbreviations: Tk/Mass/1/65, A/turkey/Massachusetts/1/65 (H6N2); Sh/Au/1/72, A/shearwater/Australia/1/72 (H6N5); Tl/HK/W312/97, A/teal/Hong Kong/W312/97 (H6N1); WHO, World Health Organization.
b
Titers in bold face are for homologous sera; <, no inhibition was detected at a serum dilution of 1:40.
c
Inactivated Tl/HK/W312/97 (H6N1) influenza virus.