TABLE 4.

Mean HIV-1 RNA concentrations after seroconversion and relative hazard of AIDS by CCR2-CCR5 haplotypes and genotypes in MACS Caucasians

Haplotype or genotype (n)	Mean plasma HIV-1 RNA concna at interval:					RH of AIDSc
	<6 mo (4.1)b	6–18 mo (12.5)b	19–30 mo (23.7)b	31–42 mo (36.2)b	6–42 mo (18.1)b
Overall mean (n = 341)	4.33	4.29	4.33	4.30	4.31
Haplotype carriers
A (60)	4.37	4.30	4.29	4.26	4.28	0.79
C (239)	4.38	4.29	4.38	4.29	4.32	1.07
D (0)
E (218)	4.28	4.36	4.40	4.29	4.35	1.56d
F*1 (2)					4.63
F*2 (64I) (69)	4.13	4.13	4.05	4.35	4.17	0.80
G*1 (27)	4.24	4.17	4.44	4.33	4.29	0.84
G*2 (Δ32) (66)	4.20	4.00	4.07	4.15	4.09	0.71
Genotypes
A/A (5)	4.78	4.50	4.38	4.39	4.41	0.75
A/C (14)	4.65	4.40	4.45	4.31	4.39	0.85
A/E (20)	4.37	4.41	4.47	4.23	4.38	1.11
A/F*2 (5)	3.87	4.29	4.12	4.72	4.37	1.86
A/G*2 (11)	3.89	3.70	3.54	3.82	3.69	0.26
C/C (44)	4.46	4.43	4.36	4.24	4.35	0.71
C/E (73)	4.30	4.33	4.50	4.20	4.35	1.69d
C/F*2 (26)	4.31	4.21	4.11	4.41	4.23	0.70
C/G*1 (10)	4.38	4.04	4.51	4.66	4.31	0.47
C/G*2 (26)	4.40	4.08	4.36	4.36	4.26	1.26
E/E (39)	4.57	4.57	4.53	4.62	4.57	1.44
E/F*2 (19)	3.91	4.18	4.06	4.28	4.17	0.88
E/G*1 (10)	3.97	4.05	4.05	3.85	3.99	1.33
E/G*2 (18)	4.12	4.25	4.11	4.11	4.16	0.63
F*2/F*2 (3)	4.47	3.56	3.93	3.45	3.73	0.95
F*2/G*2 (9)	4.11	3.46	3.42	3.76	3.50	0.47
G*2/non-A (55)	4.24	4.06	4.10	4.17	4.11	0.86
Others (8)	4.50	4.47	4.49	4.59	4.51

^aExpressed as mean log₁₀ plasma HIV-1 RNA (copies per milliliter) based on ≥1 measurement available within interval.

^bRange (median) of interval (months) between estimated seroconversion and median date of HIV-1 RNA assay.

^cBased on Cox proportional hazards models.

^dFor RH of AIDS in men carrying genotype of interest compared with all others in the cohort, P < 0.01.