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. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 10.

Figure 10

Bcl-xL suppresses PPARγ expression and multiple gene sets involved in metabolic pathways. (A) Bubble plots showing the GSEA analysis with Hallmark gene sets. Sigmoid curve showing the result with CHOLESTEROL HOMEOSTASIS gene set. (B) RT-PCR of Pparg in KPA and KPAB organoids (n = 4/group). The P value was calculated using a t test. (C) Western blotting of PPARγ in KPA and KPAB organoids (n = 2/group). (D) GFP (green) and PPARγ (red) staining in KPA and KPAB xenografts. The rates of PPARγ-positive cells were quantified (n = 3/group). The P value was calculated using a t test. (E) PPARγ (red) staining in M-A and M-AB mice. The rates of PPARγ-positive cells were quantified (n = 3/group). The P value was calculated using a t test. Scale bars, 100 μm. Mean ± standard error of the mean. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.