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. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 2.

Figure 2

The deletion of Bcl-xL reduces tumor burden in Apc-deficient tumors. (A) Ki67 (green) staining in WT and M-B mice. The rates of the Ki67+ cells are quantified (n = 3/group). The P value was calculated using a t test. (B) Ki67 staining in M-A and M-AB mice. The rates of the Ki67+ cells are quantified (n = 3 mice/group). The P value was calculated using a t test. (C) β-catenin (green) and Ki67+ (red) staining in M-A mice. The rates of the Ki67+ cells are quantified, comparing non-nuclear and nuclear β-catenin cells (n = 3 mice/group). The P value was calculated using a t test. (D) tdTOMATO (red) and Ki67+ (green) staining in M-A mice. The rates of the Ki67+ cells are quantified, comparing tdTOMATO-positive and -negative cells (n = 3 mice/group). The P value was calculated using a t test. (E) Bcl-xL (red) and β-catenin (green) staining in WT mice (representative images for n = 3 mice/group). (F) Bcl-xL (red) and β-catenin (green) staining in M-A and M-AB mice. The rates of Bcl-xL+ cells and β-catenin–nuclear–translocated cells were quantified (n = 3 mice per group). In M-A mice, the rates of β-catenin–nuclear-translocated cells were quantified, comparing Bcl-xL-low and -high expressing cells (n = 3 mice per group). The P value was calculated using a t test. (G) β-catenin (green) staining in M-A and M-AB mice 2 weeks, 1 month, and 2 months after tamoxifen induction. The average number of β-catenin–nuclear-translocated cells per one clone were quantified (n = 10 clones per mouse, n = 3 mice per group). The P value was calculated using a t test. Scale bars, 100 μm. Mean ± standard error of the mean. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.