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. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 4.

Figure 4

Bcl-xL deletion suppresses Wnt signaling in APC-deficient gastric epithelium. (A) Cleaved caspase 3 staining in WT, M-B, M-A, and M-AB mice (Representative images for n = 3 mice/group). (B) Cleaved caspase 3 (red) and E-cadherin (green) staining in M-B and M-AB mice 7 days and 1 month after TAM induction (representative images for n = 3 mice/group). (C) YAP staining in WT, M-B, M-A, and M-AB mice. The rates of YAP-positive cells were quantified (n = 3/group). The P value was calculated using a t test. (D) RT-PCR of Lgr5, Axin2, Sox9, Fzd7, Ccnd1, Lgr4, and cMyc in M-A and M-AB mice (n = 9 mice/group). The P value was calculated using a t test. Scale bars, 100 μm. Mean ± standard error of the mean. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.