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. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 5.

Figure 5

Apc-deficient gastric organoids are sensitive to Bcl-xL inhibition. (A) The schema of the lentivirus-infected organoid development. (B–D) Treatment with Bcl-xL inhibitor (A-1155463) in WT and Apc organoids. (B) The representative images of the organoids. (C) The transitions of organoid diameters were quantified (n = 10/group). The P value was calculated using a t test. (D) Western blotting with cleaved caspase 3, caspase 3, and β actin in WT organoids with and without Bcl-xL inhibitor. Scale bars, 100 μm. Mean ± standard error of the mean. ∗P < .05.