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. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 7.

Figure 7

Bcl-xL deletion suppresses the proliferation via inactivation of Wnt/β-catenin pathway in xenograft models. (A) Gross findings of the KPA and KPAB xenografts. The tumor sizes were quantified (n = 5/group). The P value was calculated using a t test. (B) GFP (green) and Bcl-xL (red) staining in KPA and KPAB xenografts. The rates of Bcl-xL + cells were quantified (n = 3/group). The P value was calculated using a t test. (C) GFP (green) andβ-catenin (red) staining in KPA and KPAB organoids. The rates of β-catenin–nuclear-translocated cells were quantified (n = 3/group). The P value was calculated using a t test. (D) GFP (green) and cyclin D1 (red), GFP (green) and SOX9 (red), GFP (green) and Ki67 (red), and GFP (green) and YAP (red) staining in KPA and KPAB xenograft. The rates of cyclin D1-, SOX9-, Ki67-, and YAP-positive cells were quantified (n = 3/group). The P value was calculated using a t test. (E) GFP (green) and cleaved caspase 3 (red) staining in KPA and KPAB xenografts. The rates of cleaved caspase 3–positive cells were quantified (n = 3/group). The P value was calculated using a t test. Scale bars, 100 μm. Mean ± standard error of the mean. ∗P < .05. DAPI, 4′,6-diamidino-2-phenylindole.