Skip to main content
. 2026 Sep 8;21(1):101880. doi: 10.1016/j.jcmgh.2026.101880

Figure 8.

Figure 8

Comparative bulk RNA sequencing analysis of WT, KPA, and KPAB gastric organoids. (A–F) Bulk RNA sequencing comparing WT, KPA, and KPAB organoids (n = 2/group). (A) PCA plots. (B) Heatmap of gene expression. (C) Heatmap showing the Tff1, Tff2, Muc5ac, Muc6, and Mki67 expression. (D) Sigmoid curve showing the result of the GSEA with Gene Ontology Biological Process (GOBP) WNT SIGNALING PATHWAY, WP WNT SIGNALING PATHWAY. v2025, and GOBP EPITHELIAL CELL PROLIFERATIOHN gene sets. (E) Heatmaps showing the top 100 differentially expressed genes (DEGs) across the 3 groups. (F) Venn diagram of the downregulated DEGs in KPA organoids and upregulated DEGs in KPAB organoids.