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. Author manuscript; available in PMC: 2026 Oct 23.
Published in final edited form as: JCO Clin Cancer Inform. 2026 Feb 5;10:e2500126. doi: 10.1200/CCI-25-00126

Appendix Table A5.

Cancer mortality rate ratios according to counties clustered by health factors included in the adapted 2014 County Health Rankings Model of Health, US (N = 3,079 counties)a

Health Factor
Clusterb
Z-score range N,
Countiesc
All cancer Lung Colorectal Breast (female) Prostate (male)
1 (most healthy) −1.40 to −0.82 109 1 (ref) 1 (ref) 1 (ref) 1 (ref) 1 (ref)
2 −0.81 to −0.54 278 1.14 (1.10-1.17) 1.22 (1.16-1.29) 1.10 (1.05-1.15) 1.08 (1.03-1.12) 1.10 (1.04-1.16)
3 −0.54 to −0.32 464 1.26 (1.22-1.29) 1.46 (1.38-1.54) 1.22 (1.17-1.27) 1.15 (1.10-1.20) 1.19 (1.13-1.26)
4 −0.32 to −0.12 460 1.33 (1.29-1.37) 1.64 (1.56-1.73) 1.31 (1.25-1.37) 1.15 (1.11-1.20) 1.20 (1.14-1.27)
5 −0.12 to 0.07 493 1.39 (1.35-1.43) 1.76 (1.67-1.85) 1.40 (1.35-1.47) 1.22 (1.17-1.27) 1.25 (1.18-1.32)
6 0.08 to 0.27 419 1.48 (1.44-1.52) 1.96 (1.85-2.06) 1.54 (1.47-1.61) 1.29 (1.23-1.35) 1.31 (1.23-1.39)
7 0.27 to 0.48 351 1.52 (1.48-1.57) 2.09 (1.98-2.21) 1.61 (1.53-1.70) 1.26 (1.19-1.33) 1.25 (1.16-1.35)
8 0.48 to 0.72 266 1.53 (1.48-1.58) 2.09 (1.97-2.22) 1.65 (1.56-1.76) 1.27 (1.19-1.36) 1.39 (1.28-1.52)
9 0.72 to 1.03 159 1.63 (1.57-1.70) 2.28 (2.12-2.44) 1.93 (1.77-2.09) 1.42 (1.28-1.58) 1.55 (1.35-1.78)
10 (least healthy) 1.04 to 1.76 80 1.60 (1.52-1.69) 2.06 (1.86-2.28) 1.79 (1.58-2.01) 1.28 (1.11-1.46) 1.34 (1.11-1.61)
a

Data presented as age-adjusted mortality rate ratios (with 95% confidence interval. All cancer mortality rates are for the years 2018-2022.

b

Clusters are arranged in order from most to least healthy characteristics.

c

Represents the total number of counties in each cluster for all cancer sites combined. The number of counties for each outcome is: all cancer – 3,079; lung cancer – 2,745; colorectal cancer – 2,180; breast cancer – 1,778; prostate cancer – 1,612.