TABLE 1.
Azole minimum inhibitory concentration (MIC) profiles against clinical isolates of Coccidioides species cultured from patients in U.S. institutions between 2001 to 2015 and 2016 to 2025a
| MIC parameters | Fluconazole | Itraconazole | Voriconazole | Posaconazole | Isavuconazole |
|---|---|---|---|---|---|
| 2001–2015 (previously published) | |||||
| Number | 581 | 486 | 499 | 377 | --- |
| Range | 01.25–>64 | ≤0.03–>16 | ≤0.03–8 | ≤0.03–>16 | --- |
| MIC50 | 8 | 0.25 | 0.125 | 0.125 | --- |
| MIC90 | 16 | 0.5 | 0.25 | 0.25 | --- |
| MIC97.5 | 64 | 1 | 1 | 0.5 | --- |
| MIC99 | 64 | 4 | 2 | 1 | --- |
| GM MIC | 7.77 | 0.245 | 0.107 | 0.141 | --- |
| Mode | 8 | 0.5 | 0.125 | 0.25 | --- |
| 2016-2025 | |||||
| Number | 1643 | 1256 | 1468 | 1247 | 782 |
| Range | 0.25 –>64 | ≤0.03–>16 | ≤0.03–4 | ≤0.03–1 | ≤0.03–8 |
| MIC50 | 8 | 0.125 | 0.125 | 0.06 | 0.25 |
| MIC90 | 16 | 0.5 | 0.25 | 0.25 | 1 |
| MIC97.5 | 64 | 1 | 0.5 | 0.5 | 2 |
| MIC99 | >64 | 1 | 1 | 0.5 | 2 |
| GM MIC | 8.85 | 0.427 | 0.350 | 0.076 | 0.332 |
| Mode | 8 | 0.125 | 0.125 | 0.06 | 0.25 |
a
MIC50, MIC90, MIC97.5, and MIC99, MIC values at which 50, 90, 97.5, and 99% of the isolates were inhibited, respectively; GM MIC, geometric mean MIC; ---, not available for Isavuconazole for 2001-2015.