Table 1.
Spray-drying parameters and characteristics of blank YDGP β-glucan particles.
| Batches | Inlet temperature (°C) | Aspirator | Outlet temperature (°C) | Pump flow rate (mL/min) | Yield (g) | Yield (%) | Drug-to-polymer ratio (g:g) | Leucine concentration (mg/g) |
|---|---|---|---|---|---|---|---|---|
| YDGP-A | 145 °C | 50% | 45 °C | 5 mL/min | 3.48 g | 17.5 | 1:1 | 100 mg |
| YDGP-B | 150 °C | 50% | 50 °C | 5 mL/min | 4.08 g | 20.5 | 1:1 | 200 mg |
| YDGP-C | 155 °C | 50% | 55 °C | 5 mL/min | 4.48 g | 22.5 | 1:1 | 300 mg |
| Characteristics of drug-loaded glucan particles (GP) | ||||||
|---|---|---|---|---|---|---|
| Batches | d 0.1 (μm) | d 0.5 (μm) | d 0.9 (μm) | Drug-loading efficiency (%) | Mass median aerodynamic diameter (MMAD; μm) | Geometric standard deviation (GSD) |
| DYDGP-A | 0.210 μm | 5.800 μm | 19.315 μm | 67% | 1.58 | 1.43 |
| DYDGP-B | 0.374 | 4.320 | 6.341 | 68% | 2.07 | 1.81 |
| DYDGP-C | 0.908 μm | 1.413 μm | 3.496 μm | 70% | 1.02 | 1.63 |