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. 2005 May 13;6(6):563–569. doi: 10.1038/sj.embor.7400416

Figure 2.

Figure 2

Shh is required for upregulation of p57Kip2 and downregulation of cyclin E2. (A) p57Kip2 transcript is expressed in a domain surrounding the central retina of wild-type embryos at 37 hpf. (C) At 42 hpf, the p57Kip2 expression domain has moved towards the retinal margin. (B,D) shh mutants lack p57Kip2 expression at any stage. (E,F) At 37 hpf, cyclin E2 is expressed in the central retina of wild-type (E) and shh−/− embryos (F). (G) At 48 hpf, cyclin E2 is expressed at the margin in the wild-type retina. (H) shh mutants fail to downregulate cyclin E2 expression in the central retina at 48 hpf.