TABLE 2.
Classification of LCV-specific genes based on evolutionary analysis
| LCV gene class | Sequence | Gene | Description |
|---|---|---|---|
| Ancestral (present in all LCVs) | Conserved | BLLF1-gp350 | |
| BZLF2-gp42 | |||
| BILF1-gp64 | |||
| BZLF1 | Transactivator | ||
| EBNA-1 | Latent gene | ||
| BHRF1 | Bcl-2 homologue | ||
| BALF1 | Bcl-2 homologue | ||
| LF1 | Unknown function | ||
| LF2 | Unknown function | ||
| Divergent | BILF2-gp78 | ||
| LMP2 | Latent gene | ||
| EBNA-LP | Latent gene | ||
| EBNA-2 | Latent gene | ||
| EBNA-3 | Latent gene | ||
| LMP1 | Latent gene | ||
| BHLF1 | Unknown function | ||
| Acquired (present only in Old World LCVs) | |||
| BCRF1 vIL-10 | Immunomodulator | ||
| BARF1 CSF-1R | Immunomodulator | ||
| BDLF3-gp150 | |||
| EBERs | Latent gene | ||
| BARF0 | Latent gene | ||
| BLLF2 | Unknown function | ||
| LF3 | Unknown function | ||
| ECRF4 | Unknown function | ||
| BNLF2s | Unknown function |