Table 3.
Surgical management, perioperative complications, and outcomes by care pathway
| Characteristic | Overall (N = 166) | Urgent (n = 122) | Scheduled (n = 44) | p value |
|---|---|---|---|---|
| Hospital course | ||||
| Diagnosis-to-surgery, days | 7 [1–290] | 5 [1–169] | 25 [7–290] | < 0.001 |
| Preoperative LOS, days | 3 [0–12] | 4 [0–12] | 0 [0–3] | < 0.001 |
| Index LOS, days | 7 [1–39] | 8 [1–39] | 3 [2–15] | < 0.001 |
| Postoperative LOS, days | 3 [1–27] | 4 [1–27] | 3 [1–12] | 0.002 |
| ICU LOS, days | 1 [0–16] | 1 [0–16] | 1 [0–6] | 0.261 |
| Days alive & at home, 30 d (DAH-30) | 18 [0–29] | 15 [0–29] | 27 [0–28] | < 0.001 |
| Surgical | ||||
| Gross-total resection | 66 (40) | 48 (39) | 18 (41) | 0.859 |
| Awake craniotomy | 16 (9.6) | 8 (6.6) | 8 (18) | 0.036 |
| 5-ALA fluorescence | 57 (34) | 37 (30) | 20 (45) | 0.095 |
| Complications (30-day) | ||||
| Any postoperative complication | 57 (34) | 44 (36) | 13 (30) | 0.465 |
| Any surgical complication | 47 (28) | 37 (30) | 10 (23) | 0.436 |
| Any medical complication | 21 (13) | 18 (15) | 3 (6.8) | 0.289 |
| New/worsened neurologic deficit (permanent) | 21 (13) | 15 (12) | 6 (14) | 0.796 |
| Surgical-site infection | 7 (4.2) | 6 (4.9) | 1 (2.3) | 0.677 |
| Intracranial hemorrhage | 8 (4.8) | 7 (5.7) | 1 (2.3) | 0.683 |
| CSF leak | 6 (3.6) | 6 (4.9) | 0 (0) | 0.343 |
| New postoperative seizure | 6 (3.6) | 5 (4.1) | 1 (2.3) | 1.000 |
| Venous thromboembolism (post-op DVT/PE) | 8 (4.8) | 7 (5.7) | 1 (2.3) | 0.683 |
| Outcomes | ||||
| Return to OR ≤ 30 d (all cause) | 13 (7.8) | 12 (9.8) | 1 (2.3) | 0.188 |
| Readmission ≤ 30 d (all cause) | 21 (13) | 17 (14) | 4 (9.1) | 0.597 |
| 30-day mortality | 4 (2.4) | 4 (3.3) | 0 (0) | 0.574 |
| Non-home discharge | 77 (46) | 65 (53) | 12 (27) | 0.004 |
| Adjuvant timing | ||||
| Surgery-to-radiotherapy, days | 36 [17–66] | 36 [17–66] | 39 [23–62] | 0.673 |
| Surgery-to-chemotherapy, days | 37 [17–145] | 36.5 [17–145] | 39.5 [23–144] | 0.356 |
Values are median [range] (Mann–Whitney U) or no. (%) (Fisher’s exact). Deficits are permanent (persisting to 3 months; deficits unresolved at death or last follow-up before 3 months were classified as permanent). Adjuvant timing is among patients with a recorded interval (radiotherapy n = 143; chemotherapy n = 142). DAH-30, days alive and at home within 30 days; LOS, length of stay; OR, operating room