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Reduced BDV transcript levels in the cerebellum specimens of GF-IL-12 mice. (A) RNase protection assays were performed as described in Materials and Methods. Note the very low levels of transgene (tg) expression in the cerebellum specimens of five GF-IL-12 mice. (B) Quantification of IL-12 and BDVp40 gene expression in the cerebellum of wild-type (wt) and GF-IL-12 mice that expressed the transgene revealed highly significant differences (P ≤ 0.002 [Mann-Whitney]).
