Table 3.

LME results for longitudinal regional volume

A	β Time	CI 95%	T Stat	f2 Time	Change to baseline [%]	p-Value
Putamen	−0.024	[−0.032, −0.017]	−6.22	0.025	−4.18	<0.001
WM	−0.103	[−0.15, −0.056]	−4.42	0.021	−5.50	<0.001
GM	−0.206	[−0.315, −0.097]	−3.78	0.02	−3.54	<0.001
Pons	−0.046	[−0.056, −0.035]	−8.61	0.018	−6.21	<0.001

B	β Phenotype			f2 Phenotype	MSA-P vs MSA-C [%]
Putamen	−0.12	[−0.18, −0.07]	−4.37	0.53	−19.18	<0.001
WM	0.28	[0.02, 0.53]	2.16	0.13	16.49	0.030
GM	0.48	[1, 1.85]	1.85	0.09	8.82	0.070
Pons	0.17	[0.05, 0.3]	2.78	0.22	27.33	0.010

A Longitudinal effects of time on ROI volumes, expressed as β coefficients, 95% CI, t-statistics, Cohen’s f² effect sizes and percent change relative to baseline normalized by ICV. B Cross-sectional effects of motor phenotype (MSA-P vs MSA-C) on ROI volumes, reported as β coefficients, 95% CI, t-statistics, Cohen’s f² and group differences expressed as percent ICV. Rows shown in bold indicate results surviving Bonferroni correction for multiple comparisons.

CI confidence intervals, ICV intracranial volume, MSA-P Parkinson phenotype, MSA-C cerebellar phenotype, GM cerebellar gray matter, WM cerebellar white matter.