Table 4.

Demographic information. Normally distributed variables are reported as mean ± standard deviation

	MSA all	MSA-C	MSA-P	P-value MSA-C vs MSA-P
Sample size	36	25	11
Age at BL	60.6 ± 6.4	60.9 ± 5.9	59.7 ± 7.7	0.6a
Sex	18 F/18 M	12 F/13 M	6 F/5 M	>0.9b
FUP time (years)	0.96 (0.20)	0.97 (0.19)	0.97 ± 0.14	0.9a
MCI status at BL	20 no/16 yes	13 no/12 yes	7 no/4 yes	0.7b
Disease duration (years)	3 (2)	3.0 ± 1.4	2.9 ± 1.3	0.8c
UMSARS-I at BL	19.1 ± 5.2	18.2 ± 4.3	21.2 ± 6.6	0.1c
UMSARS-I at FUP	25.0 ± 5.9	24.6 ± 5.1	26.0 ± 7.4	0.5c
	HC	P-value HC vs MSA
Sample Size	50
Age	63.9 ± 9.2	0.07a
Sex	26 F/24 M	>0.9b

Non-normally distributed variables are reported as median (interquartile range).

BL baseline, FUP follow-up, MCI Mild Cognitive Impairment, UMSARS-I Unified Multiple System Atrophy Rating Scale Part I, HC healthy controls.

^aT-test.

^bexact Fisher test for categorical variables.

^cMann-Whitney U test.