Figure 1.

Model for yeast AspRS feedback regulation and potential effects of AspRS on the nuclear population of mRNA^Asp. The three-dimensional structure of one monomer of the AspRS core (Ruff et al, 1991) is given (in light brown) with the modelled amino-terminal extension (in blue; Frugier et al, 2000) appended to the anticodon-binding domain. The location of the RNA-binding domain in the second helix of the appendix (in magenta) and its binding with tRNA are indicated (Frugier et al, 2000). The steps that are potentially affected during the regulation process are indicated in red.