Figure 2.

Adjusted mean differences (β) in child MSEL Composite and T-scores at 6, 12, 24, and 36 months of age associated with a doubling in prenatal maternal urinary concentrations of six OPE biomarkers detected in ≥60% of samples and with detected versus non-detected concentrations of three OPE biomarkers detected in <60% of samples. Biomarkers detected in ≥60% of samples were modeled as continuous log2-transformed concentrations, whereas biomarkers detected in <60% of samples were modeled as dichotomous variables (detect versus non-detect). Models were adjusted for child sex, child year of birth, homeownership, maternal age at delivery, maternal education, parity, maternal pre-pregnancy body mass index (BMI), and maternal race/ethnicity. Red and blue shaded areas represent negative and positive associations with a p-value <0.05, respectively. No associations remained significant after false discovery rate (FDR) correction (FDR <0.10).

Abbreviations: bis(butoxyethyl) phosphate (BBOEP), bis(2-chloroethyl) phosphate (BCETP), bis(1-chloro-2-propyl) phosphate (BCPP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), bis(2-ethylhexyl) phosphate (BEHP), bis(2-methylphenyl) phosphate (BMPP), the sum of di-n-butyl phosphate and di-iso-butyl phosphate (DBUP+DIBP), detection frequency (DF), diphenyl phosphate (DPHP), dipropyl phosphate (DPRP)