Fig. 1. XPak3 sequence analysis. The XPak3 protein sequence, as predicted from the cDNA, was aligned with the murine (m) and human (h) orthologues, as well as with the two other Xenopus variants, XPak1 and XPak2 (Bagrodia et al., 1995; Faure et al., 1997; Allen et al., 1998; Cau et al., 2000). Dashes represent identical amino acids while dots indicate the absence of amino acids. The kinase domain is shaded in grey. The Cdc42/Rac1-interacting binding (CRIB) domain is indicated and partially overlaps with the autoinhibitory domain (AID) indicated in bold. The proline-rich motifs (PXXP and PRM), specific for Nck and Pix interactions, are boxed. The G-β/γ-binding domain (Gbg) is conserved at the C-terminal edge. The percentages of sequence identity and similarity are indicated.