Table 3.
Associations of combinations of psychosis and other SUDs with overdose and self-harm in OAT
| Self-harm1 | Overdose1 | |||
|---|---|---|---|---|
| unadjusted OR (95% CI) | adjusted OR (95% CI)2 | unadjusted OR (95% CI) | adjusted OR (95% CI)2 | |
| Combinations of psychosis and other SUDs | ||||
| Both | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| Psychosis only | 0.15 (0.04–0.41) | 0.23 (0.06–0.67) | 0.18 (0.06–0.45) | 0.26 (0.08–0.72) |
| Other SUDs only | 0.33 (0.23–0.47) | 0.50 (0.33–0.76) | 0.32 (0.23–0.45) | 0.50 (0.34–0.76) |
| Neither | 0.10 (0.07–0.16) | 0.21 (0.12–0.36) | 0.11 (0.07–0.16) | 0.21 (0.12–0.36) |
SUD, substance use disorder; other SUDs, other substance use disorders not related to opioids; CI, confidence interval; OR, odds ratio; OAT, opioid agonist therapy; PDs, personality disorders; CCI, Charlson Comorbidity Index.
1
Logistic regression model, reporting OR for self-harm and overdose.
2
Adjusted models included combinations of psychosis and other SUDs, sex, age at first OAT, year of first OAT, place of residence, OAT medication, CCI, history of self-harm or overdose, non-SUD psychiatric disorders, mood disorders, anxiety disorders, and PDs.