TABLE 3.
Chimeric gp120 binding and entry dataa
| Protein | gp120-CD4 binding to:
|
Viral entry
|
||
|---|---|---|---|---|
| CCR5 Nt sulfopeptide | Cell surface CCR5 | CCR5 mediated | CXCR4 mediated | |
| JR-FL | +++ | +++ | +++ | − |
| JJL | ++ | − | − | ++ |
| JJΔ | +++ | − | − | − |
| JLL | − | − | − | ++ |
| JLJ | − | − | + | − |
| JLΔ | − | − | − | − |
| LAI | − | − | − | +++ |
| LLJ | − | − | ++ | − |
| LLΔ | − | − | − | − |
| LJJ | ++ | +++ | +++ | − |
| LJL | ++ | − | − | +++ |
| LJΔ | ++ | − | − | − |
a
Simplified summary of binding to CCR5 Nt sulfopeptides, binding to cell surface CCR5, and entry into CCR5- or CXCR4-expressing cells mediated by the chimeric envelope glycoproteins used in this study. The extent of binding and entry is indicated by + and − signs.