Table 1. Comparison of the groups in terms of characteristics, glaucoma severity, and plasma spermine and spermidine concentrations.
|
- |
POAG (n=51) |
EG (n=44) |
Control (n=39) |
p value |
|
Sex, n (%) | ||||
|
Female |
30 (58.8) |
20 (45.5) |
20 (51.3) |
0.425* |
|
Male |
21 (41.2) |
24 (54.5) |
19 (48.7) |
|
|
Age (years), mean ± SD |
66.7±9.2 |
67.0±6.6 |
63.9±7.6 |
0.067† |
|
BMI (kg/m2), mean ± SD |
24.4±3.2 |
24.3±3.4 |
24.6±3.0 |
0.886‡ |
|
Modified Hodapp-Parrish-Anderson stage, n (%) | ||||
|
Stage 0 |
6 (11.8) |
1 (2.3) |
39 (100) |
POAG vs. EG 0.019* |
|
Stage 1 |
22 (43.1) |
5 (11.4) |
0 |
|
|
Stage 2 |
11 (21.6) |
12 (27.3) |
0 |
|
|
Stage 3 |
10 (19.6) |
4 (9.1) |
0 |
|
|
Stage 4 |
1 (2.0) |
4 (9.1) |
0 |
|
|
Stage 5 |
1 (2.0) |
2 (4.5) |
0 |
|
|
Unknown (no data) |
0 |
16 (36.4) |
0 |
|
|
Spermine (ng/mL), mean ± SD |
358.7±124.7a |
354.3±131.8a |
307.0±157.5 |
0.005† |
|
Spermidine (ng/mL), mean ± SD |
5.08±1.45a |
4.86±1.38a,b |
4.34±1.13 b |
0.037‡ |
POAG: Primary open-angle glaucoma, EG: Exfoliation glaucoma, BMI: Body mass index, SD: Standard deviation. *Pearson chi-square, †Kruskal-Wallis, ‡One-way ANOVA. p values in bold indicate the presence of statistical significance. Same letters denote the lack of statistical significance in pairwise comparisons (Dunn’s test with adjustment for multiple comparisons following Kruskal-Wallis; Bonferroni-adjusted pairwise comparisons following one-way ANOVA)