Table 2.
Top 10 enriched metabolic pathways affected by Nopal on T2D and CRC.
| Metabolic Pathway Name | ID | Source | p-value | Hit in Query List |
|---|---|---|---|---|
| KEGG_PATHWAYS_IN_CANCER | M12868 | KEGG Pathways |
3.11E-20 | TGFBR2, IGF1, IGF1R, EGFR, PIK3CG, PIK3R1, CASP3, AKT1, MMP1, MMP2, MAPK1, PPARD,P PARG, MMP9, MAPK8, MAPK10, MAP2K1, NOS2, PGF, PTGS2, AR, GSK3B, HSP90AA1 |
| WP_GASTRIN_SIGNALING_PATHWAY | M39866 | WikiPathways | 9.57E-15 | JAK2, MAPK14, EGFR, PIK3R1, SRC, CASP3, AKT1, MAPK1, PPARG, MAPK8, MAP2K1, IL2,PTGS2, GSK3B |
| WP_ONCOSTATIN_M_SIGNALING_PATHWAY | M39562 | WikiPathways | 9.57E-15 | JAK2, MAPK14, PIK3R1, SRC, CASP3, CASP7, AKT1, MMP1, MAPK1, MMP3, MAPK8, MAP2K1 |
| WP_AGERAGE_PATHWAY | M39420 | WikiPathways | 9.57E-15 | JAK2, MAPK14, EGFR, SRC, CASP3, AKT1,MMP2, MAPK1, MMP9, MAPK8, MAP2K1, NOS2 |
| REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING | M27874 | Reactome Pathways | 3.91E-14 | IGF1R, EGFR, PIK3R1, ESR1, ESR2, SRC, AKT1, MMP2, MAPK1, MMP3, MMP9, HSP90AA1 |
| WP_PROLACTIN_SIGNALING_PATHWAY | M39601 | WikiPathways | 3.91E-14 | JAK2, MAPK14, PIK3CG, PIK3R1, SRC, CASP3, AKT1, MAPK1, MAPK8, MAP2K1, NOS2, GSK3B |
| WP_IL3_SIGNALING_PATHWAY | MM15879 | WikiPathways | 9.25E-13 | SELP, JAK2, MAPK14, PIK3R1, SRC, AKT1, MMP2, MAPK1, MMP9, MAPK8, MAP2K1, GSK3B |
| REACTOME_SIGNALING_BY_INTERLEUKINS | M874 | Reactome Pathways | 2.13E-12 | JAK2, MAPK14, PIK3R1, CASP3, AKT1, MMP1, MMP2, MAPK1, MMP3, MMP9, MAPK8, MAPK10, MAP2K1, IL2, NOS2, PTGS2, HSPA8, HSP90AA1, SOD2 |
| KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION | M3578 | KEGG Pathways |
4.91E-12 | IGF1, IGF1R, MAPK14, PIK3CG, PIK3R1, AKT1, MAPK1, MAPK8, MAPK10, MAP2K1, HSP90AA1 |
| WP_IL2_SIGNALING_PATHWAY | MM15915 | WikiPathways | 2.31E-14 | JAK2, MAPK14, PIK3CG, PIK3R1, AKT1, MAPK1, MAPK8, MAP2K1, IL2, TERT, HSP90AA1 |