Table 2. Cox-2 genotypes and risk of advanced colorectal adenomas.
|
All
|
Males
|
Females
|
||||
|---|---|---|---|---|---|---|
| Genotypes | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI |
| −663 | ||||||
| GT/GT | 702/704 | 490/478 | 212/226 | |||
| GT/(GT)a | 32/45 | 0.65 (0.40, 1.04) | 24/36 | 0.59 (0.34, 1.02) | 8/9 | 0.95 (0.35, 2.5) |
| −798 | ||||||
| A/A | 490/493 | 339/340 | 151/153 | |||
| A/G | 233/231 | 1.017 (0.81, 1.27) | 167/158 | 1.06 (0.81, 1.39) | 66/73 | 0.91 (0.60, 1.37) |
| G/G | 18/26 | 0.80 (0.43, 1.50) | 11/16 | 0.79 (0.35, 1.76) | 7/10 | 0.82 (0.30, 2.27) |
| 5229 | ||||||
| T/T | 534/530 | 384/363 | 150/167 | |||
| T/G | 189/190 | 0.94 (0.74, 1.20) | 125/130 | 0.88 (0.66, 1.18) | 64/60 | 1.15 (0.75, 1.77) |
| G/G | 24/33 | 0.73 (0.42, 1.27) | 13/23 | 0.48 (0.24, 0.99) | 11/10 | 1.43 (0.58, 3.55) |
| 8494 | ||||||
| T/T | 311/347 | 215/244 | 96/103 | |||
| T/C | 344/318 | 1.17 (0.94, 1.46) | 249/211 | 1.31 (1.01, 1.71) | 95/107 | 0.94 (0.63, 1.41) |
| C/C | 94/91 | 1.14 (0.82, 1.59) | 59/64 | 1.02 (0.68, 1.53) | 35/27 | 1.40 (0.78, 2.53) |
OR=odds ratio; CI=confidence interval. Adjusted for age and smoking history.
a
Parentheses refers to deletion polymorphism.