Table 3. Haplotype frequencies constructed by PHASE algorithm in cases and controls, adjusted for age and smoking history.
| Haplotype |
All
|
Males
|
Females
|
|||
|---|---|---|---|---|---|---|
| Intron 5-5229 and 3′UTR-8494 | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI |
| TT | 959/1006 | 676/694 | 283/312 | |||
| TC | 298/247 | 1.26 (1.03, 1.53) | 217/165 | 1.35 (1.07, 1.70) | 81/82 | 1.06 (0.74, 1.51) |
| GC | 234/253 | 0.950 (0.77, 1.16) | 150/174 | 0.85 (0.66, 1.09) | 84/79 | 1.200 (0.84, 1.71) |
OR=odds ratio; CI=confidence interval. Adjusted for age and smoking history. Almost identical results were obtained using the PL-EM and SNPHAP algorithms.