Table 4. Cox-2 haplotypes and risk for advanced colorectal adenomas in association with tobacco usage.
| Haplotype |
Never smoker
|
Current smoker
|
Former smoker
|
|||
|---|---|---|---|---|---|---|
| Intron 5-5229 and &3′UTR-8494 | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI |
| All | ||||||
| TT | 377/458 | 142/63 | 3.12 (2.24, 4.36) | 440/485 | 1.13 (0.93, 1.38) | |
| TC | 111/109 | 1.24 (0.92, 1.68) | 42/16 | 3.71 (2.03, 6.77) | 145/122 | 1.50 (1.13, 1.99) |
| GC | 89/124 | 0.86 (0.63, 1.17) | 25/18 | 1.83 (0.97, 3.45) | 120/111 | 1.33 (0.99, 1.79) |
| Males | ||||||
| TT | 228/274 | 97/49 | 2.81 (1.89, 4.18) | 351/371 | 1.20 (0.95, 1.52) | |
| TC | 76/64 | 1.41 (0.96, 2.07) | 28/11 | 3.76 (1.80, 7.83) | 113/90 | 1.64 (1.17, 2.29) |
| GC | 47/73 | 0.74 (0.49, 1.12) | 15/13 | 1.38 (0.63, 3.01) | 88/88 | 1.28 (0.90, 1.82) |
| Females | ||||||
| TT | 149/184 | 45/14 | 4.45 (2.32, 8.51) | 89/114 | 1.00 (0.70, 1.43) | |
| TC | 35/45 | 0.99 (0.60, 1.64) | 14/5 | 3.82 (1.32, 11.0) | 32/32 | 1.25 (0.72, 2.15) |
| GC | 42/51 | 1.05 (0.65, 1.68) | 10/5 | 3.10 (1.01, 9.48) | 32/23 | 1.73 (0.96, 3.12) |
OR=odds ratio; CI=confidence interval. Adjusted for age and NSAIDs usage.