Table 5. Cox-2 haplotypes and risk for advanced colorectal adenomas in association with NSAIDs use.
| Haplotype |
None
|
Aspirin
|
Ibuprofen
|
Both
|
||||
|---|---|---|---|---|---|---|---|---|
| Intron 5-5229 and 3′UTR-8494 | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI | Cases/controls | OR 95% CI |
| All | ||||||||
| TT | 422/397 | 301/302 | 0.87 (0.70, 1.07) | 106/121 | 0.83 (0.61, 1.12) | 132/186 | 0.65 (0.50, 0.85) | |
| TC | 123/102 | 1.11 (0.82, 1.5) | 101/68 | 1.30 (0.92, 1.82) | 34/31 | 1.03 (0.62, 1.73) | 40/46 | 0.81 (0.51, 1.27) |
| GC | 97/111 | 0.77 (0.56, 1.0) | 73/67 | 0.92 (0.61, 1.32) | 25/34 | 0.69 (0.404, 1.195) | 39/41 | 0.93 (0.58, 1.48) |
| Males | ||||||||
| TT | 309/266 | 222/236 | 0.742 (0.57, 0.95) | 61/67 | 0.78 (0.52, 1.15) | 84/125 | 0.55 (0.40, 0.77) | |
| TC | 91/64 | 1.18 (0.82, 1.7) | 77/52 | 1.17 (0.79, 1.74) | 20/16 | 1.09 (0.55, 2.18) | 29/33 | 0.75 (0.44, 1.28) |
| GC | 60/74 | 0.64 (0.44, 0.9) | 53/57 | 0.69 (0.45, 1.05) | 13/20 | 0.59 (0.28, 1.22) | 24/23 | 0.92 (0.50, 1.69) |
| Females | ||||||||
| TT | 113/131 | 79/66 | 1.32 (0.87, 2.00) | 45/54 | 0.98 (0.610, 1.583) | 48/61 | 0.90 (0.57, 1.43) | |
| TC | 32/38 | 0.96 (0.55, 1.6) | 24/16 | 1.66 (0.83, 3.31) | 14/15 | 1.04 (0.47, 2.28) | 11/13 | 0.93 (0.39, 2.20) |
| GC | 37/37 | 1.11 (0.65, 1.8) | 20/10 | 2.40 (1.06, 5.40) | 12/14 | 0.90 (0.39, 2.06) | 15/18 | 1.01 (0.48, 2.13) |
OR=odds ratio; CI=confidence interval. Adjusted for age and smoking history.