TABLE 3.
Expression of proinflammatory cytokines and presence of SIVE in multiple brain regions from a macaque with encephalitis
| Region | Presence (+) or absence (−) of indicated cytokine
|
Severity of SIVEa | Distribution of SIVEb | |
|---|---|---|---|---|
| TNF-α | IFN-γ | |||
| Globus pallidus | + | + | 2 | 2 |
| Thalamus | + | + | 4 | 3 |
| Putamen | + | + | 4 | 2 |
| Frontal cortex | + | + | 4 | 3 |
| Parietal cortex | + | − | 0 | N/A |
| Occipital gray | − | − | 0 | N/A |
| Occipital white | + | + | 3 | 2 |
| Cerebellum gray | + | + | 4 | 2 |
| Cerebellum white | − | + | 4 | 2 |
a
Severity scoring system: 0, none; 1, minimal; 2, mild; 3, moderate; 4, severe.\
b
Distribution scoring system: 1, focal; 2, multifocal; 3, diffuse; N/A, not applicable (no lesions).