TABLE 3.
Probable and demonstrated function(s) of T. brucei mitochondrial editosome proteins
| Protein1 | Probable motifs/domains/family2 | Function/probable function3 | Reference |
| TbMP81 (a) | C2H2 Zn finger (PS50157) | Macromolecule interaction | Panigrahi et al. 2001b; Drozdz et al. 2002 |
| TbMP63 (a) | C2H2 Zn finger (PS50157) | Macromolecule interaction | Panigrahi et al. 2001b; Huang et al. 2002 |
| TbMP42 (a) | C2H2 Zn finger (PS50157) | Macromolecule interaction | Panigrahi et al. 2001b |
| TbMP24 (a) | S1 domain (PS50126) | RNA interaction | This study |
| TbMP18 (a) | Single-strand binding protein family (PF00436) | RNA interaction | Panigrahi et al. 2001b |
| TbMP90 (b) | Ribonuclease III (PS50142) | Nuclease | This study |
| TbMP67 (b) | Ribonuclease III (PS50142) | Nuclease | This study |
| TbMP61 (b) | Ribonuclease III (PS50142) | Nuclease | This study |
| TbMP46 (b) | Pumilio-family RNA binding (PS50303) | Macromolecule interaction | This study |
| TbMP44 (b) | Ribonuclease III (PS50142) | Structure/Nuclease | This study; B. Wang, in prep. |
| TbREL1 (c) | Ligase (CDD-7281) | RNA ligase | Panigrahi et al. 2001a; Schnaufer et al. 2001 |
| TbREL2 (c) | Ligase (CDD-7281) | RNA ligase | Panigrahi et al. 2001a; Schnaufer et al. 2001 |
| TbMP100 (d) | Endonuclease/exonuclease/phosphatase (PF03372) | Nuclease | This study |
| TbMP99 (d) | Endonuclease/exonuclease/phosphatase (PF03372) | Nuclease | This study |
| TbMP57 | PAP_core, PAP_associated, and Nucleotidyltransferase domains (PS50154, PS50155, PF01909) | Terminal uridylyl transferase | This study; N. Ernst unpubl. |
| mHel61p | DEAD box (PF00270), Helicase_C (PF00271) | Helicase | Missel et al. 1997 |
1Proteins that show sequence similarity between them have been grouped as a, b, c, and d.
2PROSITE (PS), Pfam (PF), and Conserved Domain Database (CDD) accession numbers for the motifs/domains/family are given in parentheses.
3The proteins with macromolecule interaction function may be involved in RNA–protein and/or protein–protein interactions.