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. 2003 Jun;9(6):734–745. doi: 10.1261/rna.5220703

FIGURE 1.

FIGURE 1.

Summary of known RNase P RNA–pre-tRNA interactions. At left is the consensus secondary structure of bacterial RNase P RNAs (Pace and Brown 1995). Nucleotide A248 (E. coli numbering) is boxed. Nucleotides conserved in more than 90% of bacterial RNase P RNAs are indicated. Capital letters indicate 100% conservation. Elements of ribozyme structure referred to in the text are indicated. The stacked acceptor stem and T stem-loop of pre-tRNAASP are shown on the right. The RNase P cleavage site is indicated by an arrow and the region of the 5′ leader sequence that is contacted by C5 protein is circled (Niranjanakumari et al. 1998). Solid lines indicate previously characterized interactions (Kirsebom and Svard 1994; Pan et al. 1995; Tallsjo et al. 1996). Dotted lines indicate short-range intermolecular crosslinking results between the substrate cleavage site and the ribozyme (Kufel and Kirsebom 1996; Christian et al. 1998).