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. Author manuscript; available in PMC: 2026 Oct 27.
Published in final edited form as: Mol Biol Cell. 2026 Oct 26;37(11):ar105. doi: 10.1091/mbc.E25-08-0391

Figure 2.

Figure 2.

Depletion of USP37 impairs fork progression and triggers replication stress response. (A, B, C, D) Representative images (A, B) and quantification (C, D) of phosphor-S33 RPA (pRPA) foci (A, C) or 53BP1 foci (B, D) in in HCT116 and HCT116FBW7−/− cells transfected with the indicated siRNAs and challenged with 1mM HU for 30min. Red lines signify the mean foci number. Statistical significance was determined by one-way ANOVA and the Kruskal-Wallis multiple comparisons test. (E, F) Representative images (E) and quantification (F) of DNA fiber length in HCT116 and HCT116FBW7−/− cells transfected with the indicated siRNAs. Red lines signify mean fiber length. Statistical significance was determined with the Mann-Whitney test. Scale bars in A, C, and D indicates 3μm. (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).