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. Author manuscript; available in PMC: 2026 Oct 27.
Published in final edited form as: Mol Biol Cell. 2026 Oct 26;37(11):ar105. doi: 10.1091/mbc.E25-08-0391

Figure 4.

Figure 4.

USP37 binds to TIPIN. (A) Pearson correlation of gene effect scores (DepMap Public 24Q4+Score, Chronos) of the indicated genes in the DepMap CRISPR data (**p<0.01, ****p<0.0001). (B, C) 293T cells were transfected with plasmids encoding USP37-Flag and STag-TIPIN and the expression of these exogenous proteins was measured with immunoblotting, and an interaction between the two proteins was determined by S-Tag (B) or Flag (C) pulldown/immunoprecipitation. (D, E, F) Immunoblot analysis (D) and quantification (E, F) of chromatin-bound protein levels in cells transfected with the indicated siRNAs. The bar graph represents mean and sd of relative protein levels, n=3. Statistical significance was determined by one-way ANOVA with Holm-Sidak post-test (*p<0.05). TPS = total protein stain, WCL = whole cell lysate