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Inhibition of globin mRNA translation in rabbit reticulocyte lysate by m7Gp3G (•), m27,2′-OGp4G (compound 15; ▴), and m72′dGp4G (compound 16; ♦). Natural rabbit globin mRNA was translated at 5 μg/mL in a rabbit reticulocyte lysate system, and globin synthesis was detected by incorporation of [3H]Leu into protein as described in Materials and Methods.
