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Models of human telomerase RNA. (A) Secondary structure of human telomerase RNA (adapted with permission from Elsevier © 2000, Chen et al. 2000) with the proposed long-range interactions revealed in this study indicated by the connecting lines. (B) A new model for the secondary structure of hTR with interacting residues shown by gray connecting lines. The catalytic domains (pseudoknot, CR4/CR5, and template) and localization domains (box H/ACA and CR7) are indicated.
