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. 2004 Jan;10(1):139–147. doi: 10.1261/rna.5118104

FIGURE 3.

FIGURE 3.

Secondary structure and mutation constructs of the P6.1 hairpin. Numbering corresponds to the nucleotide position in the hairpin beginning at the 5′ end. Bases in bold are 100% conserved in vertebrate telomerase RNAs (Chen et al. 2000). Hairpin A is wild-type P6.1 with the indicated mutations U7C, U8C, G9C, G10C, and G10A. UV cross-linking employed 4-thio-U modified RNA hairpins (designated as s4U7 and s4U8). Base pairing in the stem of hairpin B is disrupted whereas the loop bases remained unchanged. Hairpin C restores base pairing in the stem with an altered stem sequence.