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. 2026 Oct 9;15(20):7778. doi: 10.3390/jcm15207778
ASA American Society of Anesthesiologists
CAE Community-acquired empyema
CCI Charlson Comorbidity Index
CI Confidence interval
CNS Central nervous system
COPD Chronic obstructive pulmonary disease
CPE Complicated parapneumonic effusion
CPPE Complicated parapneumonic pleural effusion
CRP C-reactive protein
CT Computed tomography
CRediT Contributor Roles Taxonomy
DNase Deoxyribonuclease
HAE Hospital-acquired empyema
HCAE Healthcare-associated empyema
HR Hazard ratio
ICU Intensive care unit
IET Intrapleural enzyme therapy
IPFT Intrapleural fibrinolytic therapy
LDH Lactate dehydrogenase
LOS Length of hospital stay
MD Mean difference
MeSH Medical Subject Headings
MNPI Microbiological-negative pleural infection
MPPI Microbiological-positive pleural infection
NLR Neutrophil-to-lymphocyte ratio
NOS Newcastle–Ottawa Scale
OR Odds ratio
PECO Population, Exposure, Comparator, Outcome
PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analyses
PROSPERO International Prospective Register of Systematic Reviews
Q Cochran’s Q statistic
RAPID Renal function, Age, Purulence, Infection source, and Dietary factors
REML Restricted maximum likelihood
RR Risk ratio
SD Standard deviation
tPA Tissue plasminogen activator
VATS Video-assisted thoracoscopic surgery
I2 Higgins’ inconsistency statistic
τ2 Between-study variance