| ASA | American Society of Anesthesiologists |
| CAE | Community-acquired empyema |
| CCI | Charlson Comorbidity Index |
| CI | Confidence interval |
| CNS | Central nervous system |
| COPD | Chronic obstructive pulmonary disease |
| CPE | Complicated parapneumonic effusion |
| CPPE | Complicated parapneumonic pleural effusion |
| CRP | C-reactive protein |
| CT | Computed tomography |
| CRediT | Contributor Roles Taxonomy |
| DNase | Deoxyribonuclease |
| HAE | Hospital-acquired empyema |
| HCAE | Healthcare-associated empyema |
| HR | Hazard ratio |
| ICU | Intensive care unit |
| IET | Intrapleural enzyme therapy |
| IPFT | Intrapleural fibrinolytic therapy |
| LDH | Lactate dehydrogenase |
| LOS | Length of hospital stay |
| MD | Mean difference |
| MeSH | Medical Subject Headings |
| MNPI | Microbiological-negative pleural infection |
| MPPI | Microbiological-positive pleural infection |
| NLR | Neutrophil-to-lymphocyte ratio |
| NOS | Newcastle–Ottawa Scale |
| OR | Odds ratio |
| PECO | Population, Exposure, Comparator, Outcome |
| PRISMA | Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
| PROSPERO | International Prospective Register of Systematic Reviews |
| Q | Cochran’s Q statistic |
| RAPID | Renal function, Age, Purulence, Infection source, and Dietary factors |
| REML | Restricted maximum likelihood |
| RR | Risk ratio |
| SD | Standard deviation |
| tPA | Tissue plasminogen activator |
| VATS | Video-assisted thoracoscopic surgery |
| I2 | Higgins’ inconsistency statistic |
| τ2 | Between-study variance |