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Graphical representation of the affect of several parameters on frameshifting efficiency in Ty1. (A) The effect of concentration of “in-frame” A-site tRNA. (B) The effect of concentration of “out-of-frame” tRNA. (C,D) The effects of the rate constants for the repositioning of P-site tRNA, k1 and k2, depend on “instability” of the initial P-site codon:anticodon complex and “instability” of the P-site tRNA complex with the +1-frame codon, respectively.
