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. 2004 Oct;10(10):1541–1549. doi: 10.1261/rna.7112704

FIGURE 1.

FIGURE 1.

Proposed secondary structures for RNA 9, RNA 10, RNA 10Trp. Drawings are the output of BayesFold, a Bayesian RNA folding program (Knight et al. 2004; http://jaynes.colorado.edu/Bayes/). In RNA 10Trp a central region (yellow) has been replaced with a tryptophan binding site (RNA 727–44, magenta; I. Majerfeld and M. Yarus, in prep.). An arrow marks a sequence change (AU →CG; nucleotides 9–82) introduced to increase the free-energy advantage of the correct fold for the tryptophan binding site. Flanking regions contain essential complementary loop sequences (Vlassov et al. 2001; green) for RNA (9:10) complex formation and membrane binding.