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. 2026 Oct 15;15(20):7977. doi: 10.3390/jcm15207977
ACAN aggrecan
ADAMTS3 A Disintegrin and Metalloproteinases with Thrombospondin motifs type 3; procollagen N-peptidase
ADAMTS4 A Disintegrin and Metalloproteinases with Thrombospondin motifs type 4; aggrecanase-1
ADAMTS5 A Disintegrin and Metalloproteinases with Thrombospondin motifs type 5; aggrecanase-2
AGEs Advanced Glycation End Products
BMI body mass index
BP biological process
cDNA complementary DNA
COL1A1 collagen type I
COL2A1 collagen type II
COL11A2 collagen type XI
CRTAP cartilage-related protein
CT threshold cycle
CTX-II C-terminal telopeptide of type II collagen
DAMPs damage-associated molecular patterns
DEGs differentially expressed genes
dNTP deoxyribonucleotide triphosphates
ECM extracellular matrix
GEO The Gene Expression Omnibus
GLUT-1 Glucose Transporter Type 1
GO Gene Ontology
HAPLN1 hyaluronan-proteoglycan-linking protein 1
HPRT1 hypoxanthine-guanine phosphoribosyltransferase
IFP infrapatellar fat pads
IL-1β interleukin-1β
IQR Interquartile range
KOOS Knee Injury and Osteoarthritis Outcome Score
MATN1 matrilin-1
MF molecular functions
MPC mesenchymal progenitor cell
MSC mesenchymal stem cells
NIDDM non-insulin-dependent diabetes mellitus
NF-kB nuclear factor-kB
OA osteoarthritis
OARSI Osteoarthritis Research Society International
PCR polymerase chain reaction
PPI Protein–Protein Interaction
PRG4 proteoglycan 4
rho Spearman’s rank correlation coefficient
RI Rnase inhibitor
ROS Reactive oxygen species
RT reverse transcription
RQ relative expression
sCOMP Serum Cartilage Oligomeric Matrix Protein
SCX transcription factor scleraxis
TGF-β Transforming Growth Factor β
WOMAC Western Ontario and McMaster Universities Arthritis Index