FIGURE 3.
Computer-predicted structure of LeishIF4E-1. The tertiary structure of LeishIF4E-1 (A,C) was predicted by homology modeling using PDBView (B,D), based on the published crystal structure of the mouse eIF4E (Marcotrigiano et al. 1997), pdb 1EJ1a—chain a (this published 3D structure contains several minor discontinuities in the polypeptide chain). The side residues of amino acids that comprise the ligand-binding site are shown in the top panels. The ligand (m7GDP) is marked in black.