TABLE 3.

Stability of the Watson-Crick base pairs of the NC-stem

	G34–C42 base pair (%)a	G35–C41 base pair (%)a
Trajectory	HB1b	HB2b	HB3b	HB1b	HB2b	HB3b
Bound K1 RNA (-LES)	99	98	96	96	95	88
Unbound K1 RNA (-LES)	96	83	63	32	24	20
Bound K2 RNA (+LES)	70	62	53	52	44	44
Unbound K2 RNA (+LES)	62	52	36	17	15	14

^aThe percentage of trajectory frames in which the hydrogen bond is formed

^bThe three hydrogen bonds of the G-C base pairs are HB1 = N2(G)–H(G)–O2(C); HB2 = N1(G)–H(G)–N3(C); HB3 = N4(C)–H(C)–O6(G).