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. 2026 Oct 2;14(6):633. doi: 10.3390/medsci14060633
AFP alpha-fetoprotein
AJCC American Joint Committee on Cancer
AP-2γ activating enhancer-binding protein 2 gamma
AUC area under the curve
BEP bleomycin, etoposide, cisplatin
β-hCG beta human chorionic gonadotropin
Ca carcinoma
CAR-T chimeric antigen receptor T-cell therapy
CD30 cluster of differentiation 30
CD117 cluster of differentiation 117/KIT receptor
CEBM Centre for Evidence-Based Medicine
cfDNA cell-free DNA
chorio choriocarcinoma
CLDN6 claudin-6
Cq quantification cycle
CS1 clinical stage I
ctDNA circulating tumor DNA
D2-40 podoplanin immunohistochemical marker
ddPCR droplet digital polymerase chain reaction
EAU European Association of Urology
EC embryonal carcinoma
ELISA enzyme-linked immunosorbent assay
FOXA2 forkhead box A2
GCNIS germ cell neoplasia in situ
GCT germ cell tumor
GPC3 glypican-3
HALP haemoglobin–albumin–lymphocyte–platelet score
HERV human endogenous retrovirus
HNF1β hepatocyte nuclear factor 1 beta
HPL human placental lactogen
HR hazard ratio
IGCCCG International Germ Cell Cancer Collaborative Group
IHC immunohistochemistry
ISUP International Society of Urological Pathology
KIT KIT proto-oncogene receptor tyrosine kinase
LDH lactate dehydrogenase
LIN28 lin-28 homolog (pluripotency-associated RNA-binding protein)
LVI lymphovascular invasion
miR microRNA
miR-302/367 microRNA-302/367 cluster
miR-371a-3p microRNA-371a-3p
miR-373-3p microRNA-373-3p
MRD minimal residual disease
NANOG Nanog homeobox
NGS next-generation sequencing
NLR neutrophil-to-lymphocyte ratio
NPV/PPV negative/positive predictive value
NSGCT non-seminomatous germ cell tumor
OCT3/4 octamer-binding transcription factor 3/4
OGCT ovarian germ cell tumor
OS overall survival
PD-L1 programmed death-ligand 1
PFS progression-free survival
PGC primordial germ cell
PLAP placental alkaline phosphatase
PLR platelet-to-lymphocyte ratio
POU5F1 POU class 5 homeobox 1
PRAME preferentially expressed antigen in melanoma
RASSF1A Ras association domain family member 1 isoform A
RCT randomized controlled trial
RPLND retroperitoneal lymph node dissection
RTI rete testis invasion
SEER Surveillance, Epidemiology, and End Results
SII systemic immune–inflammation index
SOX2 SRY-box transcription factor 2
SOX17 SRY-box transcription factor 17
TCGA The Cancer Genome Atlas
TDS testicular dysgenesis syndrome
TF transcription factor
TFAP2C transcription factor AP-2 gamma
TGCT testicular germ cell tumor
TME tumor microenvironment
ULN upper limit of normal
VISTA V-domain Ig suppressor of T-cell activation
WHO World Health Organization
YST yolk sac tumor