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The solvent accessible surface of the hTR J6 structure, showing a tunnel through the core of the J6 region. The N3 atom of C290 (red) is only reactive to dimethyl sulfate (DMS) in the absence of the hTERT protein (Antal et al. 2002). This region is a likely binding determinant for hTERT, and we speculate that this cavity is a protein-docking site.
