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. 2005 Aug;11(8):1281–1290. doi: 10.1261/rna.5040605

FIGURE 1.

FIGURE 1.

Eukaryotic orthologs of Trm6p and Trm61p. (A) Alignment of predicted polypeptide sequences of Trm6p from Homo sapiens (H.s.) with homologous proteins from Mus musculus (M.m.), Drosophila melanogaster (D.m.), and Saccharomyces cerevisiae (S.c.). The arrowhead highlights proline 431, the amino acid changed in the temperature-sensitive stains trm6-504 and trm6-505. The asterisk indicates the substitution of glycine for glutamic acid at amino acid 299. (B) Alignment of Trm61p from H.s. with homologous proteins from eukaryotes (M.m, D.m., S.c.) as in A. The alanine at position 66, which is found as valine in sequence from the human genome, is indicated by the asterisk. Shading designates the amino acids conserved between two or more homologs.