FIGURE 1.

(A) Proposed secondary structure of FMN aptamer containing hairpin ribozymes. The aptamer sequence (domain C) replaces the hinge region as an internal junction via distinct bridge sequences (gray box), which base identities are chosen in a manner to interfere with the docking process. (B) Schematic presentation of the aptamer junction in F80 ribozyme construct. (C) Catalytic rate constants of F80 and the unmodified C1H construct (Supplementary Fig.1 at http://famulok.chemie.uni-bonn.de/publications/current/index.html) in the absence and presence of 200 μM FMN.